Replication studies

The Replication Programme has funded 23 replications through four rounds of funding. We track and maintain a list of all 3ie-funded and in-house replication studies, with details on the status of each. Every time a study progresses to a new stage, 3ie updates this list.

Please direct any questions or comments to replication@3ieimpact.org. To learn more upcoming funding opportunities and replication related events, click here.

We are also funding internal replications of influential impact evaluations in HIV Prevention and Financial Services for the Poor

Replication studies

Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial

Replication study  
Replication researchers: Baojiang Chen, Morshed Alam
Original paper title:

Task Shifting of Antiretroviral Treatment from Doctors to Primary-Care Nurses in South Africa (STRETCH): A Pragmatic, Parallel, Cluster-Randomised Trial


Original researchers: Lara Fairall, Max O. Bachmann, Carl Lombard, Venessa Timmerman, Kerry Uebel, Merrick Zwarenstein, Andrew Boulle, Daniella Georgeu, Christopher J. Colvin, Simon Lewin, Gill Faris, Ruth Cornick, Beverly Draper, Mvula Tshabalala, Eduan Kotze, Cloete van Vuuren, Dewald Steyn, Ronald Chapman, Eric Bateman
Original publication: Lancet
Replication plan:

Chen's replication plan


Current status: Completed Replication Study

Triple Antiretroviral Compared with Zidovudine and Single-Dose Nevirapine Prophylaxis During Pregnancy and Breastfeeding for Prevention of Mother-To-Child Transmission of HIV-1 (Kesho Bora study): a Randomized Controlled Trial

Replication study  
Original paper title:

Triple Antiretroviral Compared with Zidovudine and Single-Dose Nevirapine Prophylaxis During Pregnancy and Breastfeeding for Prevention of Mother-To-Child Transmission of HIV-1 (Kesho Bora study): A Randomized Controlled Trial


Original researchers: The Kesho Bora Study Group
Original publication: The Lancet Infectious Diseases
Current status: Unable to Replicate

Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival

Replication study  
Original paper title:

Prevention of HIV-1 Infection with Early Antiretroviral Therapy


Original researchers: Mari M. Kitahata, Stephen J. Gange, Alison G. Abraham, Barry Merriman, Michael S. Saag, Amy C. Justice, Robert S. Hogg, Steven G. Deeks, Joseph J. Eron, John T. Brooks, Sean B. Rourke, M. John Gill, Ronald J. Bosch, Jeffrey N. Martin, Marina B. Klein, Lisa P. Jacobson, Benigno Rodriguez, Timothy R. Sterling, Gregory D. Kirk, Sonia Napravnik, Anita R. Rachlis, Liviana M. Calzavara, Michael A. Horberg, Michael J. Silverberg, Kelly A. Gebo, James J. Goedert, Constance A. Benson, Ann C. Collier, Stephen E. Van Rompaey, Heidi M. Crane, Rosemary G. McKaig, Bryan Lau, Aimee M. Freeman, Richard D. Moore
Original publication: New England Journal of Medicine
Current status: Unable to Replicate

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

Replication study  
Original paper title:

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men


Original researchers: Robert M. Grant, Javier R. Lama, Peter L. Anderson, Vanessa McMahan, Albert Y. Liu, Lorena Vargas, Pedro Goicochea, Martín Casapía, Juan Vicente Guanira-Carranza, Maria E. Ramirez-Cardich, Orlando Montoya-Herrera, Telmo Fernández, Valdilea G. Veloso, Susan P. Buchbinder, Suwat Chariyalertsak, Mauro Schechter, Linda-Gail Bekker, Kenneth H. Mayer, Esper Georges Kallás, K. Rivet Amico, Kathleen Mulligan, Lane R. Bushman, Robert J. Hance, Carmela Ganoza, Patricia Defechereux, Brian Postle, Furong Wang, J. Jeff McConnell, Jia-Hua Zheng, Jeanny Lee, James F. Rooney, Howard S. Jaffe, Ana I. Martinez, David N. Burns, David V. Glidden
Original publication: New England Journal of Medicine
Current status: Unable to Replicate

Male Circumcision for HIV Prevention in Men in Rakai, Uganda: a Randomised Trial

Replication study  
Replication researchers: Eric Djimeu
Original paper title:

Effect of Circumcision of HIV-Negative Men on Transmission of Human Papillomavirus to HIV-Negative Women: A Randomised Trial in Rakai, Uganda


Original researchers: Ronald H. Gray, Godfrey Kigozi, David Serwadda, Frederick Makumbi, Stephen Watya, Fred Nalugoda, Noah Kiwanuka, Lawrence H. Moulton, Mohammad A. Chaudhary, Michael Z. Chen, Nelson K. Sewankambo, Fred Wabwire-Mangen, Melanie C. Bacon, Carolyn F.M. Williams, Pius Opendi, Steven J. Reynolds, Oliver Laeyendecker, Thomas C. Quinn, Maria J. Wawer
Original publication: Lancet
Current status: Unable to Replicate

Effect of Reduction in Household Air Pollution on Childhood Pneumonia in Guatemala (RESPIRE): A Randomised Controlled Trial

Replication study  
Replication researchers: Jan Hattendorf
Original paper title:

Effect of Reduction in Household Air Pollution on Childhood Pneumonia in Guatemala (RESPIRE): A Randomised Controlled Trial


Original researchers: Kirk R. Smith, John P. McCracken, Martin W. Weber, Alan Hubbard, Alisa Jenny, Lisa M. Thompson, John Balmes, Anaité Diaz, Byron Arana, Nigel Bruce
Original publication: Lancet
Current status: Unable to Replicate

Can Government-allocated Land Contribute to Food Security? Intrahousehold Analysis of West Bengal’s Microplot Allocation Program

Replication study  
Replication researchers: Benjamin DK Wood (with Maria Luisa Vasquez)
Original paper title:

Can Government-allocated Land Contribute to Food Security? Intrahousehold Analysis of West Bengal's Microplot Allocation Program


Original researchers: Florence Santos, Diana Fletschner, Vivien Savath, Amber Peterman
Original publication: World Development
Current status: Unable to Replicate

HIV Development Assistance and Adult Mortality in Africa

Replication study  
Replication researchers: Jiangtao Luo
Original paper title:

HIV Development Assistance and Adult Mortality in Africa


Original researchers: Eran Bendavid, Charles Holmes, Jay Bhattacharya, Grant Miller
Original publication: JAMA
Replication plan:

Luo's replication plan


Current status: Completed Replication Study

Timing of Antiretroviral Therapy for HIV-1 Infection and Tuberculosis

Replication study  
Replication researchers: Eric Djimeu
Original paper title:

Timing of antiretroviral therapy for HIV-1 infection and tuberculosis


Original researchers: Diane V. Havlir, Michelle A. Kendall, Prudence Ive, Johnstone Kumwenda, Susan Swindells, Sarojini S. Qasba, Anne F. Luetkemeyer, Evelyn Hogg, James F. Rooney, Xingye Wu, Mina C. Hosseinipour, Umesh Lalloo, Valdilea G. Veloso, Fatuma F. Some, N. Kumarasam
Original publication: The New England Journal of Medicine
Replication plan:

Djimeu’s Replication Plan


Current status: Completed Replication Study

The Regai Dzive Shiri Project: results of a randomised trial of an HIV prevention intervention for Zimbabwean youth

Replication study  
Replication researchers: Fang Yu, Nicholas A Hein and Danstan S Bagenda
Original paper title:

The Regai Dzive Shiri Project: results of a randomised trial of an HIV prevention intervention for Zimbabwean youth


Original researchers: Frances M Cowan, Sophie JS Pascoe, Lisa F Langhaug, Webster Mavhu, Samson Chidiya, Shabbar Jaffar, Michael Mbizvo, Judith M Stephenson, Anne M Johnson, Robert M Power, Godfrey Woelk, Richard J Hayes
Original publication: Lancet
Replication plan:

Yu's replication plan


Current status: Completed Replication Study