PEPFAR and adult mortality: a replication study of HIV development assistance effects in Sub-Saharan African countries

PEPFAR and adult mortality: a replication study of HIV development assistance effects in Sub-Saharan African countries

3ie Replication Paper 15

Nicholas A Hein, Danstan S Bagenda and Jiangtao Luo

In this paper, Nicholas Hein and colleagues conducted a replication of the 2012 publication HIV development assistance and adult mortality in Africa by Eran Bendavid and colleagues. The original study investigated the relationship between increased funding to sub-Saharan African countries through the President’s Emergency Plan for AIDS Relief (PEPFAR) and adult mortality. It concluded that during the years of PEPFAR implementation (2004-2008), the odds of adult mortality was significantly lower in PEPFAR sub-Saharan countries as compared to non-PEPFAR sub-Saharan countries.

A few minor discrepancies did not change the original authors’ conclusions of the study. The replication study reproduced results that supported the original authors’ published conclusions. Additionally, the team replicated both individual- and country-level modeling adjustments, to a 2010 study by Duber and colleagues that did not find a statistically significant effect of the PEPFAR program on all-cause mortality in Sub-Saharan countries between 2000 and 2006. They found that PEPFAR had a significant impact on all-cause adult mortality when examining the effects of PEPFAR using an unadjusted model, as well as after adjustment with country-level covariates

However, modeling adjustments with both country and individual level covariates resulted in borderline insignificant findings of association between PEPFAR funding and all-cause adult mortality. Therefore, the replication researchers cautiously support the findings by the original authors.

3ie Replication paper 18

Savings revisited: a replication study of a savings intervention in Malawi

Replication paper 3ie 2018

Jesper Stage and Tharshini Thangavelu replicate the results of a randomized evaluation carried out by Lasse Brune and colleagues in 2016 in Malawi.

RPS19

Mobile money and its impact on improving living conditions in Niger: a replication study

Replication paper 3ie

Edmundo Beteta and colleagues replicate the results of a randomized evaluation carried out by Aker and colleagues in 2016 in Niger.

3ie Replication Paper 17

Thou shalt be given... but how? A replication study of a randomized experiment on food assistance in northern Ecuador

Replication paper 3ie 2018

Lhachimi and Seuring re-examine the results of a cluster-randomized evaluation carried out by Melissa Hidrobo and colleagues in 2013 in two provinces in northern Ecuador.

RP16

Preventing HIV and HSV-2 through improving knowledge and attitudes: a replication study of a multicomponent intervention in Zimbabwe

Replication paper 3ie 2018
Yu and colleagues conducted a replication study of an influential paper “The Regai Dzive Shiri Project: results of a randomised trial of an HIV prevention intervention for Zimbabwean youth” by Frances Cowan and colleagues.

RP14

When to start ART? A replication study of timing of antiretroviral therapy for HIV-1-associated Tuberculosis

Replication paper 3ie 2018
In this paper, the research team conducted a replication study of Havlir and others’ 2011 study, “Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.”