RP14

When to start ART? A replication study of timing of antiretroviral therapy for HIV-1-associated Tuberculosis

3ie Replication paper 14

Eric W. Djimeu

In this paper, the research team conducted a replication study of Havlir and others’ 2011 study, “Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.” The original study tackled the issue of optimal timing for ART initiation in HIV-TB co-infected patients by conducting a large multisite trial in 26 countries to determine the impact of earlier ART (within 2 weeks of the initiation of treatment for tuberculosis) on new AIDS-defining illness and death. The original authors find that earlier ART initiation reduces the rate of new AIDS-defining illness and death only for HIV positive TB patients with a CD4 count lower than 50.

In this replication study, the researcher team conducted a pure replication and measurement and estimation analyses. In general, the pure replication confirmed the main findings of the original paper. In addition, the research team found that earlier ART initiation is associated with a sharp increase in the incidence of TB-associated immune reconstitution inflammatory syndrome (IRIS). Furthermore, using mainly econometric approaches to increase the statistical power of the study and to estimate the treatment effect on patients who actually received earlier ART. The research team find that earlier ART initiation do not reduce the rate of new AIDS-defining illness and death even for HIV-positive TB patients with CD4 counts lower than 50.

Overall, the results of this replication do not provide strong support that earlier ART initiation reduces the rate of new AIDS-defining illness and death only for HIV-positive TB patients with CD4 counts lower than 50.

3ie Replication paper 18

Savings revisited: a replication study of a savings intervention in Malawi

Replication paper 3ie 2018

Jesper Stage and Tharshini Thangavelu replicate the results of a randomized evaluation carried out by Lasse Brune and colleagues in 2016 in Malawi.

RPS19

Mobile money and its impact on improving living conditions in Niger: a replication study

Replication paper 3ie

Edmundo Beteta and colleagues replicate the results of a randomized evaluation carried out by Aker and colleagues in 2016 in Niger.

3ie Replication Paper 17

Thou shalt be given... but how? A replication study of a randomized experiment on food assistance in northern Ecuador

Replication paper 3ie 2018

Lhachimi and Seuring re-examine the results of a cluster-randomized evaluation carried out by Melissa Hidrobo and colleagues in 2013 in two provinces in northern Ecuador.

RP16

Preventing HIV and HSV-2 through improving knowledge and attitudes: a replication study of a multicomponent intervention in Zimbabwe

Replication paper 3ie 2018
Yu and colleagues conducted a replication study of an influential paper “The Regai Dzive Shiri Project: results of a randomised trial of an HIV prevention intervention for Zimbabwean youth” by Frances Cowan and colleagues.

RP13

Stretching HIV treatment: A replication study of task shifting in South Africa

Replication paper 3ie 2017
Baojiang Chen and Morshed Alam conducted a replication study of Fairall and other’s influential paper, “Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH)”.