Transparency, Reproducibility, and Ethics (TRE)

3ie champions the research transparency and reproducibility movement as a means of understanding and mitigating challenges to the credibility of social science research, while also working toward stronger integration of ethical principles into practice. Through integration of TRE principles and practices in 3ie research workflow, 3ie aims to ensure: (i) the rigor and credibility of research activities by asking demand-driven questions and mitigating intentional and unintentional scientific misconduct; and (ii) research activities follow foundational principles of research ethics: respect for persons, beneficence, and justice. 


The 3ie Transparency, Reproducibility, and Ethics (TRE) Policy articulates the organization’s commitment to delivering the resources and expertise research teams need to achieve TRE objectives: to ensure rigor and credibility of research and adhere to the principles of ethical research. The TRE Policy defines how TRE work is guided by 3ie’s ethical principles: 

  • Everyone with whom 3ie research staff comes into contact, regardless of sex, age, gender identity, disability, sexual orientation, ethnic origin, religion, or caste, has the right to be protected from all forms of harm, abuse, neglect and exploitation.
  • Research transparency, reproducibility, and ethics are integral to research rigor.
  • Foundational ethics – respect for persons, beneficence, and justice – are standards based on fundamental human rights.
  • Ethics should be as focused on the purpose of the research activity and producing meaningful analyses for improving development effectiveness as it is to ensure the protection of the health and safety of the research participants and team.
  • Ethics requires considering the potential unintended consequences of conducting the research and weighing these as additional benefits and/or costs.
  • Ethical standards require the means to monitor and address concerns throughout the research life cycle.

The primary focus of the TRE Helpdesk is to support research teams on: 

  1. Training on incorporating TRE within the research life cycle;
  2. Training in protection of human subjects;
  3. Study registration on 3ie’s RIDIE, as well as other relevant registries;
  4. Pre-analysis Plan (PAP) or protocol review and publication on RIDIE and 
  5. Adherence to standardized reporting and citation requirements for publications.

The Helpdesk is also available to support researchers on data management, de-identification, and push-button replication through the TRE Data Center and on navigating ethical issues through TRE Review. 

The primary focus of the TRE Data Center is to support research teams on:  

  1. Defining who has access to identifiable data and when and how that data may, or may not, be shared through Data Management Plans and/or Data Sharing Agreements
  2. Establishment of secure data transfer and storage practices
  3. Review of data de-identification protocols to mitigate re-identification risk and adhere to promises of confidentiality
  4. Integration of Push-Button Replication (PBR) protocols into analysis workflow to improve computational reproducibility
  5. Data sharing on the 3ie Dataverse, or other data sharing platforms. 

The primary focus of the TRE Review is to support research teams on:  

  1. Strengthening the informed consent review, pilot, and implementation process to ensure appropriate engagement with research participants on key issues related to research purpose, risk, benefits, and data-sharing practices
  2. Engaging with Institutional Review Board (IRB) for specific research activities based on local, journal, funding, and other requirements
  3. Conducting independent review of 3ie-defined TRE practices to assess research design, implementation, and dissemination for alignment with ethical principles
  4. Ensure alignment between promises of confidentiality and the data de-identification and sharing practices. 

3ie understands that evidence-based policy to improve development outcomes requires credible, rigorous research methods. Just as 3ie called attention to the need for evidence to inform project design and implementation, there is a need for evidence to inform certain decisions in research design and implementation. TRE research aims to answer specific questions, including: 

  1.  Does incorporating TRE into research practice improve research quality and credibility? What evidence exists and where are the evidence gaps? 
  2. What ethical concerns do research teams have? What evidence exists on potential best practices and where are the evidence gaps? 
  3. How are TRE publications – registries, PAPs – used to strengthen meta-analysis and systematic reviews?
  4. Do data-sharing efforts enable additional analysis and learning opportunities? What questions related to development effectiveness can be answered with open data?

For more information, please write to mentioning '3ie TRE' in the subject line.